It sounds to me like the skeptics need to be more skeptical. The serotonin hypothesis for depression has long been discredited. Well-designed studies have shown that anti-depressants are no more effective than placebos. Psychiatrists have spent more than 100 years inventing pseudoscience like SSRIs and the DSM. It is too bad that skeptics have mistaken their unhappiness and brain functioning for "mental illness". Psychiatric drugs are not the answer; they are the escape from the answer.